Novartis and Exelixis are big market movers

NEW YORK (AP) — Stocks that moved substantially or traded heavily Tuesday on the New York Stock Exchange and the Nasdaq Stock Market:

NYSE

Novartis AG, up $3.43 to $93.47

The drug developer presented positive data for a potential heart-failure drug and will ask for approval by the end of the year.

Las Vegas Sands Corp., down $3.41 to $63.10

The casino operator and its gambling company peers experienced a decline in revenue from the gambling hub Macau during August.

Cloud Peak Energy Inc., down $1.27 to $14.44

The coal company lowered its coal shipment and adjusted earnings guidance for 2014, citing rail issues and weather impacts.

Crown Holdings Inc., up $1.85 to $50.12

The packaging products company is buying the Mexican can packaging business of brewer Heineken for just under $1.23 billion.

Nasdaq

Exelixis Inc., down $2.29 to $1.85

The biotechnology company said its potential treatment for prostate cancer failed to meet a key goal in a late-stage study.

Conns Inc., down $13.83 to $31

The consumer goods retailer reported second-quarter profit below Wall Street expectations and cut its full-year profit guidance.

Norwegian Cruise Line Holdings Ltd., up $3.68 to $36.99

The cruise line will buy Prestige Cruises International for about $3 billion and expects to close the deal in the fourth quarter.

Acadia Pharmaceuticals Inc., up $2.63 to $26.61

The biotechnology company received a special FDA designation for its potential Parkinson's disease psychosis treatment, Nuplazid.