U.S. stocks closed mostly lower Tuesday after five straight days of gains. DuPont and energy companies rose sharply, but the overall market was weighed down by health-care stocks, especially biotechnology companies.

U.S. stocks closed mostly lower Tuesday after five straight days of gains. DuPont and energy companies rose sharply, but the overall market was weighed down by health-care stocks, especially biotechnology companies.

On Tuesday:

The Dow Jones industrial average rose 13.76 points, or 0.1 percent, to close at 16,790.19.

The Standard & Poor's 500 index lost 7.13 points, or 0.4 percent, to 1,979.92.

The Nasdaq composite fell 32.90 points, or 0.7 percent, to 4,748.36.

For the week:

The Dow is up 317.82 points, or 1.9 percent.

The S&P 500 index is up 28.56 points, or 1.5 percent.

The Nasdaq is up 40.59 points, or 1.9 percent.

For the year:

The Dow is down 1,032.88 points, or 5.8 percent.

The S&P 500 index is down 78.98 points, or 3.8 percent.

The Nasdaq is up 12.31 points, or 0.3 percent.